Do we give MMR vaccine via the intramuscular (IM) or subcutaneous (SC) route?

The Ministry of Health recommends that MMR vaccine is administered via the IM route. However, administration of MMR vaccine by either the IM or SC injection route delivers a valid dose of vaccine.

In the original clinical trials, MMR vaccine was given by SC injection and this became the recommended route of injection. Since then, data have shown that administration of MMR vaccine by IM injection generates an immune response equal to the response when the vaccine is given via the SC route, and the vaccine is also well-tolerated.

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Can we give the 12-months MMR1 vaccines earlier than 12 months of age?

There are no clinical concerns with MMR1 administration up to one month before age 12 months, but it requires a prescription as it is outside of licensure. It will be considered an exception error and the dose does not need to be repeated. Otherwise, 4 days before the child is 12 months.

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Can we give the 15-months varicella, Hib and MMR2 vaccines earlier than 15 months of age?

On parental request, the varicella and Hib vaccine doses due at 15 months of age can be given a maximum of 4 days before the child is aged 12 months.

The MMR2 vaccine dose due at 15 months of age is not recommended to be given early, unless there is a high risk of exposure to these diseases, such as during an outbreak.

When there is a high risk of exposure to measles, mumps or rubella, 15-months MMR2 dose can be administered as early as 4 weeks after the MMR1 dose.

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‍Should older children who have missed one or both doses of the MMR vaccine still have the vaccine?

Yes. A total of two documented doses of MMR vaccine are recommended for all children and adults born after 1968. When two catch-up doses of MMR are required, they can be given a minimum of four weeks apart.

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Do children who received a measles only or measles/rubella vaccine overseas need MMR vaccination?

Yes. Two doses of the MMR vaccine given from 12 months of age are recommended irrespective of previous measles or measles/rubella only vaccination.

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Do children who have had measles still need to receive the MMR vaccine?

Yes. Two doses of MMR vaccine are recommended to protect the child from mumps and rubella.

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Can a close contact of a woman who is pregnant or of a person who is immunocompromised receive the MMR vaccine?

Yes. MMR vaccine viruses are considered to be non-transmissible. It is also important to reduce the risk of the mother and those who are immunocompromised being exposed to measles disease.

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How long should a woman wait to get pregnant after receiving the MMR vaccine?

As a precautionary measure, women should be advised to avoid becoming pregnant for 28 days after receiving MMR vaccine. However, if she becomes pregnant within 28 days of MMR vaccination, there are international data that can reassure the woman the vaccination is not expected to cause harm to the fetus.

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What happens if a woman receives MMR vaccine and then finds out she was pregnant at the time or within 4 weeks of the vaccination?

No additional pregnancy monitoring or management is required. There are international data that can reassure the woman the vaccination is not expected to cause harm to the fetus. The advice not to give MMR vaccine to a woman who knows she is pregnant is based on a theoretical risk that the vaccine viruses could cause maternal or fetal disease.

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Can a pregnant woman receive the MMR vaccine?

Live vaccines are not given to pregnant women. However, if an MMR vaccine is given in error there are international data that can reassure the woman the vaccination is not expected to cause harm to the fetus.

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How soon after having a baby can a woman receive the MMR vaccine?

As soon as baby has been delivered.

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Can a breastfeeding woman receive the MMR vaccine?

Yes. There is no risk to the mother or child from giving MMR to breastfeeding women.

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What do we do when a woman’s antenatal rubella serology result reports she is not immune to rubella?

A woman is considered to be immune to rubella if she has two documented doses of MMR vaccine, given from 12 months of age and at least four weeks apart, regardless of serology.

If she does not have two documented doses of MMR vaccine, administer catch-up doses of MMR vaccine after the baby has been delivered. When two doses of MMR are required, they can be given a minimum of four weeks apart.

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Can a person with an egg allergy receive the MMR vaccine?

Yes. Neither egg allergy nor anaphylaxis are contraindications for receipt of the MMR vaccine.

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Should we order serology to check for measles immunity?

No. Evidence of immunity for adults born prior to 1969 is simply being born before 1969. Evidence of immunity for adults born in 1969 or later is two documented doses of MMR vaccine.

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What if there is no available documentation available for a person presenting for a ‘catch up’ dose of MMR?

There is no need to delay, the vaccinator should feel confident to offer a dose of MMR vaccine to the patient. There are no safety concerns if a person is given an extra dose of MMR vaccine.

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Do adults aged 18 years or over need MMR revaccination if they have had chemotherapy or radiotherapy for cancer?

If the person was considered immune before chemotherapy, they are still considered immune to measles, mumps and rubella after completion of treatment and immune system recovery.

Chemotherapy and radiotherapy for cancer does not remove immune system memory cells.

Adults born before 1969 and living in New Zealand are considered immune to measles and vaccinating these individuals post chemotherapy is not indicated.

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Can a person who is immunocompromised receive the MMR vaccine?

No. If your patient has a medical condition or is on a treatment that affects their immune system, refer to chapter 4 in the current Immunisation Handbook for more information on treatments and timing of vaccination.

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Is there a single antigen measles vaccine available in NZ?

No. The measles vaccine is only available as one of the components of the MMR vaccine in NZ. There is no immunological or medical reason for offering a single measles vaccine and it is important to offer protection for rubella and mumps.

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Can adults have the MMR vaccine?

Adults born in 1969 or later

Yes. Two documented doses of MMR vaccine given at least four weeks apart are recommended for individuals born in 1969 or later.

For those who have:

• two documented doses of MMR are considered immune. No more MMR vaccinations are required.
• one documented dose of MMR prior to chemotherapy should receive a second dose of MMR vaccine, OR
• do not have any documented doses of MMR vaccine should receive two doses of MMR vaccine six months post chemotherapy and when their lymphocyte count is greater than 1.0 x 109/L.

Only pre-HSCT (stem cell or bone marrow transplant) conditioning completely removes a person’s immune system including memory cells. Re-vaccination with MMR vaccine usually occurs 2 years after HSCT.

‍Adults born before 1969 in New Zealand or overseas‍
Immunity to measles is assumed in people who lived in NZ prior to 1969. ‍

Other people who lived in countries with limited circulating measles*‍ prior to 1969 may not be immune to measles if not previously immunised with a measles-containing vaccine. Therefore, they can be considered for funded MMR vaccination, particularly in the case of a community outbreak.

Those born prior to 1969 do not need to be recalled for MMR vaccination but may benefit from a clinical discussion about their risk. 

‍*Countries with limited circulating measles prior to 1969 include remote island nations. 

‍Consider MMR vaccination needs by age groups‍
‍70s or older: ‍People aged in their 70s and older do not need MMR vaccine
‍Mid-50s and 60s: ‍People aged in their mid-50s and in their 60s are very unlikely to need a MMR vaccine, but it can be considered if necessary
‍Adults up to mid-50s: ‍People aged younger than mid-50s need MMR if they do not have a clear record of two doses of measles containing vaccine or confirmed measles. Two doses, at least 4 weeks apart

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CALL 0800 IMMUNE (0800 466 863) for clinical advice

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