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Common name:


Protects against diphtheria, tetanus, pertussis (whooping cough) and polio.



Infanrix®-IPV is given as a booster vaccine at 4 years of age. The primary course of these vaccines (diphtheria, tetanus, pertussis [also called whooping cough] and polio) are included in the Infanrix-hexa vaccine given at 6 weeks, 3 months and 5 months.

This (pertussis containing) vaccine may be withheld from a child with an unstable, evolving neurological condition until their condition has stabilised. In this event your doctor will assess your child and discuss with you.

Responses to vaccine

Infanrix-IPV (DTaP-IPV)

Common Responses

  • Mild pain, redness and swelling around injection site
  • Decreased appetite
  • Vomiting or diarrhoea
  • Irritability, restlessness
  • Unusual crying
  • Limb swelling

Rare Responses

  • Hives
  • Temporary low platelet count
  • Persistent inconsolable screaming in infants
  • Hypotonic, hyporesponsive episode (HHE) in infants
  • Convulsion

As with any medicine, very rarely a severe allergic reaction (anaphylaxis) can occur following immunisation.


Centers for Disease Control and Prevention. General Recommendations on Immunization Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011;60(2):1-61.

Ministry of Health. Immunisation Handbook 2017 2nd Edition. Ministry of Health: Wellington. Available from: http://www.health.govt.nz/publication/immunisation-handbook-2017.

In Depth

Other brands: None containing the same combination of antigens

Related vaccines: DTaP-IPV- Hib/HepB (Infanrix®-hexa) and IPV (IPOL®)

Vaccine type: subunit

Vaccine Schedule

Infanrix®-IPV is funded as a booster vaccine at 4 years of age.

Special groups

Infanrix-IPV is not funded for special groups.

Catch-up doses

Infanrix-IPV is funded for use in catch-up schedules for children up to their 10th birthday.

Vaccine storage and preparation

No special considerations, store as per cold chain between 2°C to 8°C.


Infanrix-IPV can be administered concurrently with other vaccines, including all the National Immunisation Schedule vaccines. Separate syringes and different injection sites should be used.

The vaccine is given intramuscularly in either the vasterus lateralis or deltoid.

Infanrix-IPV should not be administered to children after their 10th birthday, or to adults. Refer to the catch-up section of the current Immunisation Handbook.

Vaccine safety

Infanrix-IPV should not be given to:

  • Anyone with severe allergy (anaphylaxis) to a previous dose of this vaccine or other diphtheria, tetanus, pertussis or polio containing vaccine, or a component of the vaccine
  • Administration of Infanrix-IPV should be postponed in individuals suffering from a fever over 38°C. The presence of a minor infection is not a reason to delay immunisation

Specialist advice should be sought for the following groups:

  • Those with bleeding disorders, such as haemophilia The vaccine should be administered in accordance with the haematologist’s instructions. It may, in this situation only, be given subcutaneously.

In the case of a child with a clinically unstable evolving neurological disorder, withholding vaccination until the clinical situation has stabilised should be considered on an individual basis after careful consideration of the risks and benefits.

Children with a personal history of a hypotonic hyporesponsive episode (HHE) can have the vaccine.

Infanrix-IPV can be given to a child with a family history of Sudden Unexplained Death of an Infant (SUDI) or convulsions following a diphtheria, tetanus and pertussis vaccination.

Vaccine effectiveness

After administration of a booster dose of Infanrix-IPV more than 99.5% of children demonstrated protective antibody titre of >0.1 IU/mLs against tetanus and diphtheria. All vaccine recipients demonstrated a marked increase in protective antibody levels, with respect to pre-booster levels, against all three serotypes of polio covered by the vaccine.

After administration of a booster dose of Infanrix-IPV a booster response was also seen in the majority of vaccinees against the pertussis antigens; lower response rates were seen where the pre-vaccination levels of antibodies were high. All vaccine recipients were seropositive one month after the booster dose, however, it should be noted no serological correlation of protection has been established for pertussis. Collection of data from secondary contacts, in households where there was an index case with pertussis, found that the protective efficacy of the vaccine was 84-88.7%.

Last updated: Jan 2019