0800 Immune

0800 466 863

Pneumococcal conjugate vaccines turning the tide on inequity – a retrospective cohort study of New Zealand children born 2006-2015

Background

Hospitalization rates for infectious diseases in New Zealand (NZ) children have increased since 1989. The highest burden is among Māori and Pacific children, and the most socioeconomically deprived. NZ introduced pneumococcal conjugate vaccine (PCV)7 in June 2008, PCV10 in 2011 and PCV13 in 2014.

Methods

A retrospective cohort study of NZ children aged <6 years between 2006 and 2015 using administrative databases. Demographics and hospitalizations were linked to evaluate the impact of the PCV vaccination program on cases of invasive pneumococcal disease (IPD), all-cause pneumonia (ACP), and otitis media (OM), defined by ICD-10-AM codes, and to explore the effect by ethnicity and deprivation.

Results

Between 2006 and 2015, there were 640 children hospitalized with IPD, 26,589 for ACP, and 44,545 for OM. IPD hospitalizations declined by 73% between 2005 and 2015 for children <6 years of age, while ACP and OM declined by 8% and 25%, respectively. The highest rates for all diseases were among Māori and Pacific, and those from high deprivation. However, the declines were highest among Māori and Pacific children and those from socioeconomically deprived areas. IPD hospitalizations declined by 79% and 67% for Māori Pacific children, respectively, between 2006 and 2015. ACP declined by 12% in Māori and 21% in Pacific children. Otitis media declined by 51% in Māori children.

Conclusion

In contrast to the increasing trend of hospitalization rates for infectious disease in NZ, the use of PCV appears associated with reductions in ethnic and socioeconomic disparities in hospitalization for IPD, ACP and OM.

Publication 
Clinical Infectious Diseases 68:5, 818-826 March 2019
Author 
Petousis-Harris H, Howe AS, Paynter J, Turner N and Griffin J
Date 
19 July 2018
Type of Research 
Year 
2019
Menu Category 
Publication Date 
Thursday, July 19, 2018

Last updated: Jul 2019