Other brands: Adacel®
Other diphtheria, tetanus, pertussis-containing vaccines: DTaP-IPV- Hib/HepB (Infanrix®-hexa) and DTaP-IPV (Infanrix®-IPV)
Vaccine type: subunit
Schedule and administration
Boostrix® is funded, and often provide as part of school-based immunisation programmes, at 11 years of age (Year 7).
It is also funded during weeks 28-38 of pregnancy, for each pregnancy, to boost maternal antibody levels, which are naturally transferred through the placenta. This helps to protect the ne born baby from pertussis, and also protects the infant from tetanus in early life (passive immunity).
Boostrix is recommended, though not funded unless provided by employers, for:
- Health care staff who work with infants less than one year of age
- Staff working in long term care facilities
- Early childhood education staff
- Students in training for occupations with children
- Household and other close contacts of infants less than one year of age
- Adults with a medical condition not specified in the Schedule but in whom prevention of pertussis is important, e.g. those with chronic respiratory/lung disease
Boostrix is funded for:
- pregnant women for each pregnancy (see box)
- adults post-haematopoietic stem cell transplant (up to four additional doses)
Catch-up doses of Boostrix are funded for children and adolescents from 10 years to under 18 years of age who require catch-up immunisation against these diseases, including those who missed their 11 year old booster immunisation.
Boostrix, may be used, and is funded, for children aged between 7-10 years instead of Infanrix-hexa (DTaP-IPV-HepB/Hib) or Infanrix-IPV (DTaP-IPV), when Hib, hepatitis B or polio protection is not required. Boostrix is not approved for use in a primary course or for children in the 7–10 years age group. However, no safety concerns are expected with off-label use. Vaccine choice will be determined by the antigens required and parental consent.
Storage and preparation
No special considerations, store as per cold chain between 2°C to 8°C.
Boostrix can be administered concurrently with other vaccines, including all the National Immunisation Schedule vaccines. Separate syringes and different injection sites should be used.
The vaccine is administered intramuscularly, into the deltoid.
Boostrix is funded for use in catch-up schedules in children and young people from aged 7 years up to 18th birthday.
Pertussis protection for newborn babies
Boostrix is recommended and funded for pregnant women between 28-38 weeks gestation.
- For best protection of the newborn the booster immunisation would be given by the end of the 36th week of pregnanc to:
- allow time for the woman's immune system to produce antibody protection against pertussis (whooping cough)
- reduce the risk that she will catch pertussis and pass it to her baby at delivery
- reduces the risk that she will pass pertussis to her baby for the subsequent year when the baby at highest risk of complications from pertussis and until baby is fully protected by their own immunisations
- ensure there is enough time before birth for high levels of antibodies to pass through the placenta into the baby to provide baby with its own temporary protection against severe disease. (This protection varies between mothers and babies but can remain for at least two months)
- If a Boostrix vaccine is delivered after 38 weeks of pregnancy there may not be adequate time for the woman’s antibody levels to be boosted to pass good protection to baby before birth, however, it will increase the woman's protection against pertussis, and reduce the risk that she will have the disease during the baby's first year of life when their risk of complications from pertussis is highest.
- After delivery of the baby, administering the Boostrix vaccine (to the mother) will increase her protection against pertussis, reducing the risk that she will have the disease, and therefore risk passing it to her baby, during the baby's first year of life when their risk of complications from pertussis is very high. It will not protect the baby in the earliest weeks of their life when they are at the very highest risk.
Boostrix should not be given to:
People in the following groups shouls seek specialist advice before receiving the vaccine:
Those with bleeding disorders, such as haemophilia. The vaccine should be administered in accordance with the haematologist’s instructions. It may, in this situation only, be given subcutaneously
In the case of a child with a clinically unstable evolving neurological disorder, withholding vaccination until the clinical situation has stabilised should be considered on an individual basis after careful consideration of the risks and benefits.
Women who are breastfeeding can safely have Boostrix. No adverse consequences for breastfed infants have been observed following vaccination of lactating women.
After administration of Boostrix to individuals who have previously completed a primary course of tetanus, diphtheria and pertussis immunisations serology of nine in 10 individuals demonstrated protection against tetanus and diphtheria.
Since, unvaccinated children from 7 years of age and adults are expected to have some immunity to pertussis as a result of exposure to the disease in the community, a single dose of Boostrix is expected boost their existing protection against pertussis. However, a single dose of Boostrix will not provide protection against tetanus and diphtheria in a previously unvaccinated person.
The current estimate from the CDC around Tdap vaccination is that 70% of adolescents, who have previously been fully immunised with DTaP as part of their primary infant series, will be protected against pertussis. Adolescents and adults who received Tdap and still get pertussis have less severe disease with fewer coughing fits, shorter illness and less likely to have disease complications.
One research paper suggests that the effectiveness of Tdap against pertussis wanes within 2-4 years in adolescents who have only received acellular pertussis vaccines during their lifetime. Therefore, it is especially important for young mothers to receive a Tdap booster during pregnancy.
When given in pregnancy, studies in the UK have shown that more than 9 out of 10 infants are protected against severe pertussis in the first 8 weeks of life. US based studies have also demonstrated that prenatal Tdap vaccination significantly reduces the risk of hospitalisation and death of young infants from pertussis and that it was 85% more effective than vaccination of mothers after birth (within 14 days postpartum).
Pertussis immunity following vaccination only lasts for around 5 years, and repeat doses are needed in those most at risk of infection, such as health and child care workers.