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Engerix-B replaces HBvaxPRO on Schedule until 2019

HBvaxPRO® 5 mcg and 10 mcg strength vaccines are currently out of stock

  • Stock is not expected to be available until early 2019.

Engerix®-B 20 mcg/mL is the funded hepatitis B vaccine for: 

  • Children and young adults aged under 18 years, to catch-up missed doses of vaccine, or who are considered not to have achieved a positive serology and require additional vaccination.
  • Adults aged 18 years or older who meet the 'special groups' eligibility criteria.

HBvaxPRO® 40 mcg stock continues to be available

  • HBvaxPRO 40 mcg is funded for adults aged 18 years or older who are on renal dialysis or who are liver or kidney transplant patients. 

Engerix-B is used in the same manner as HBvaxPRO 5 mcg and 10 mcg

  • The full dose of 20 mcg/mL is administered to eligible neonates, infants, children and adults.
  • Do not attempt to administer less than the full dose provided in the pre-filled Engerix-B syringe.

There are no concerns about increased vaccine responses to Engerix-B 20 mcg

  • Common, expected vaccine responses are similar for all hepatitis B vaccine strengths and include mild pain, redness and swelling around injection site, nausea or vomiting, abdominal pain, diarrhoea, decreased appetite.

It is safe to administer 1 mL of vaccine into the vastus lateralis (VL) of neonates and infants

  • The maximum recommended volume for an intramuscular (IM) injection into the VL of neonates and infants is 1 mL. If a neonate is due for hepatitis B immunoglobulin (HBIG), hepatitis B vaccine and vitamin K, we continue to recommend that the HBIG and vitamin K be given IM in one VL, separating the injection sites by 2–3cms and the hepatitis B vaccine be given in the other VL.

Engerix-B 20 mcg can be used for the adolescent two-dose schedule

  • Based on safety and immunogenicity data supporting the interchangeability of vaccine brands, a two-dose course of Engerix-B 20 mcg can be considered for adolescents aged 11–15 years, with the second dose given 4–6 months after the first. This schedule is expected to provide the same level of protection as the two-dose HBvaxPRO 10 mcg schedule for adolescents.

Please refer to the Hepatitis B chapter in the Immunisation Handbook 2017 2nd Edition

Information is also available on our HBvaxPRO vaccine page

  • Eligibility for funded hepatitis B vaccination

  • Vaccine administration

  • Catch-up schedules

 

Last updated: Mar 2018